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High-throughput analysis of aqueous drug solubility, supersaturation, and aggregation behaviour using second harmonic light scattering

Abstract Aqueous solubility is a crucial physicochemical property influencing drug absorption and bioavailability. Current solubility assays, whether assessing thermodynamic or kinetic solubility, involve trade-offs between accuracy, detection limit, speed, and resource consumption. Therefore, this study introduces a novel approach to drug solubility assessment based on non-resonant second harmonic scattering (SHS), which detects interfacial flu…
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Pharma Excipients broke the news in on Saturday, October 18, 2025.
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