HDAC11 Deficiency Slows Muscle Aging

HDAC11 Deficiency Slows Muscle Aging

Researchers have found that genetic engineering to reduce expression of HDAC11 favorably changes the metabolism of muscle tissue in mice regardless of age. In older mice this alteration slows the well known loss of muscle mass and strength and improves muscle regeneration. Interestingly, HDAC11 inhibitor small molecules have been identified by the cancer research community, so the next step is to assess the ability of these drugs to improve musc…