US EditionPublished • loading... • Updated
Enzyme Technology Enables First Successful Blood Type Conversion in Kidney Transplant
The enzyme-converted kidney functioned without rejection for two days in a brain-dead recipient, marking progress toward reducing wait times for type-O patients who are over 50% of waitlists.
- On Oct. 3, University of British Columbia scientists reported a kidney converted from type A to type O was transplanted into a brain-dead recipient with family consent using special enzymes.
- Amid severe organ shortages, type-O transplant candidates make up over 50% of kidney waitlists and typically wait 2-4 years longer, while over 100,000 people await donor organs in the United States.
- Researchers used two enzymes to perfuse a discarded type-A kidney for about two hours, converting it while the organ showed no hyperacute rejection for two days before mild markers reappeared on day 3.
- Regulatory approval for clinical trials is the next hurdle, and Avivo Biomedical will lead development toward blood-type mismatched deceased-donor transplants.
- The breakthrough follows the early 2010s research timeline and builds on a 2022 type-A lung conversion, with Dr. Stephen Withers saying, `This is the first time we've seen this play out in a human model.
Insights by Ground AI
11 Articles
11 Articles
Change blood type, tested on a kidney (ANSA)
·Italy
Read Full Article
Enzyme technology enables first successful blood type conversion in kidney transplant
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed at the University of British Columbia to help prevent a mismatch and rejection of the organ.
·United States
Read Full Article
Enzyme technology clears first human test toward universal donor organs for transplantation
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed at the University of British Columbia to help prevent a mismatch and rejection of the organ.
First human transplant of kidney modified to have ‘universal’ blood type
Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types. Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.
·United Kingdom
Read Full ArticleCoverage Details
Total News Sources11
Leaning Left1Leaning Right0Center5Last UpdatedBias Distribution83% Center
Bias Distribution
- 83% of the sources are Center
83% Center
L 17%
C 83%
Factuality
To view factuality data please Upgrade to Premium
