Electrophysiology and morphology of human cortical supragranular pyramidal cells in a wide age range

Electrophysiology and morphology of human cortical supragranular pyramidal cells in a wide age range

The basic excitatory neurons of the cerebral cortex, the pyramidal cells, are the most important signal integrators for the local circuit. They have quite characteristic morphological and electrophysiological properties that are known to be largely constant with age in the young and adult cortex. However, the brain undergoes several dynamic changes throughout life, such as in the phases of early development and cognitive decline in the aging bra…