DNA Microscopy Creates 3D Maps of Life From the Inside Out

Spatial transcriptomic imaging of an intact organism using volumetric DNA microscopy

Lymphatic, nervous and tumor tissues exhibit complex physiology arising from three-dimensional interactions within genetically unique microenvironments. Here we develop a technology capable of volumetrically imaging transcriptomes, genotypes and morphologies in a single measurement, without relying on prior knowledge of spatial organization or genetic sequences. Our method extends DNA microscopy into three dimensions at scales involving 107 mole…

DNA Microscopy Creates 3D Maps of Life From the Inside Out

What if you could take a picture of every gene inside a living organism—not with light, but with DNA itself? Scientists at the University of Chicago have pioneered a revolutionary imaging technique called volumetric DNA microscopy. It builds intricate 3D maps of genetic material by tagging and tracking molecular interactions, creating never-before-seen views inside organisms [...]

DNA scaffolds enable self-assembling 3D electronic devices - Tech and Science Post

Researchers at Columbia Engineering have for the first time used DNA to help create 3D electronically operational devices with nanometer-size features. “Going from 2D to 3D can dramatically increase the density and computing power of electronics,” said corresponding author Oleg Gang, professor of chemical engineering and of applied physics and materials science at Columbia Engineering and leader of the Center for Functional Nanomaterials’ Soft a…

DNA microscope offers new 3D view of organisms from inside out

Scientists at the University of Chicago have introduced “volumetric DNA microscopy,” which has the potential to transform our understanding of biology by producing detailed, three-dimensional images of organisms at the molecular level. For the first time, this technology can provide a spatial map of gene expression for an entire organism. Traditional genetic sequencing provides valuable… The post DNA microscope offers new 3D view of organisms fr…

DNA Microscope Creates 3D Images of Organisms from the Inside Out

Current genetic sequencing techniques can provide much information about the genetic makeup and activity in a sample, like a piece of tissue or a drop of blood. But they are unable to reveal where specific genetic sequences were located inside that sample, or their relationship to other genes and molecules, according to University of Chicago (UChicago) scientists, who say they are developing a novel method that overcomes these challenges. By tag…

For several decades, biologists have been trying to unravel the mystery of chromosome condensation into characteristic sticks following cell division. An international team has just taken a decisive step in visualizing this phenomenon with unprecedented precision, thanks to a new technology-based imaging method for DNA tracing, LoopTrace. Their work reveals that DNA folds first into large loops, then into a series of smaller and intertwined stru…