US EditionDesign of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells - Pharma Excipients
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Design of lipid-based formulations for oral delivery of a BASP1 peptide targeting MYC-dependent gastrointestinal cancer cells - Pharma Excipients
Abstract Hypothesis Oral delivery of the proliferation-inhibiting brain acid-soluble protein 1 effector domain peptide (Myr-NT) towards MYC-dependent gastrointestinal tumors can be achieved by forming hydrophobic ion pairs (HIPs) and incorporating them into lipid-based formulations. Highlights BASP1 effector peptide was encapsulated into a nanoemulsion via HIP formation. Formulation boosted cellular uptake and limited enzymatic degradation of…
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