Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate - Pharma Excipients

Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate - Pharma Excipients

Abstract We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution, porosity and content uniformity, were measured to determine granule characteristics. The set of experiments was based on a central composite design fac…