Clusterin identified as key marker for aging in blood stem cells

Clusterin identified as key marker for aging in blood stem cells

In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the biological mechanisms of aging.

Clusterin expression marks aging in hematopoietic stem cells

In recent years, there has been a growing trend of an aging patient population and an increasing prevalence of age-associated diseases, underscoring the need for advancing research into the biological mechanisms of aging. Of particular scientific interest are hematopoietic stem cells (HSCs), which undergo profound age-related phenotypic and functional transformations.

Increase of Clusterin Protein Could Protect from Alzheimer’s Disease

In a new study published in Neuron titled “CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density,” researchers from Mass General Brigham have identified a potential strategy to protect against Alzheimer’s disease (AD) by increasing the clusterin (CLU) protein, a molecular chaperone that binds misfolded proteins. Their results uncover the mechanism of how increased CLU pr…

Senolytics as a Treatment for Aging and Immunosenescence

Senolytic drugs capable of selectively destroying senescent cells in aged tissues are probably the most immediately promising of present efforts to treat aging as a medical condition. It is unfortunate that so little work presently takes place to rigorously evaluate the well established low-cost generic drug and supplement senolytics in human patients, as the animal studies suggest that they could be very beneficial. Unfortunately the high costs…