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Christian McCaffrey injury: 49ers RB questionable for Week 1 vs. Seahawks; says it is 'nothing serious'

Christian McCaffrey, limited by injuries last season, is doubtful for the Week 1 game but reports no serious issues ahead of the NFL opener.

  • Christian McCaffrey, the running back for the 49ers, has been designated as questionable for the team's Week 1 matchup against the Seahawks due to a calf injury.
  • McCaffrey’s calf issue emerged during Thursday’s practice, leading him to leave early and not participate in Friday's full practice, while coach Kyle Shanahan declined to disclose specific details.
  • Despite the injury, McCaffrey continued warmups on the side with team director Mike Sola, said he felt good, planned to play, and described the injury as "nothing serious."
  • McCaffrey has a history of injuries including Achilles tendinitis and a PCL tear that limited him to four games in 2024, but he managed his workload well during a healthy 2025 offseason and training camp.
  • If McCaffrey cannot play, the 49ers plan to rely on recently acquired running back Brian Robinson Jr., who they traded for two weeks ago, underscoring a need for depth at the position.
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The San Francisco Standard broke the news in on Friday, September 5, 2025.
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