Base Editors Curb Repeating DNA in Huntington’s and Ataxia Models

Base Editors Curb Repeating DNA in Huntington’s and Ataxia Models

Armed with base editors, scientists from the laboratory of David Liu, PhD, professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, and their collaborators elsewhere, successfully made changes to the defective gene responsible for Huntington’s disease and Friedreich’s ataxia. Their results are described in a Nature Genetics paper published this week titled “Base editing of trinucleotide …