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Immunosuppression for Immune-Related Adverse Events During Checkpoint Inhibition: an Intricate Balance

Summary by Nature
Immune checkpoint inhibitors (ICIs) have changed perspectives for patients with cancer, but come with severe immune-related adverse events (irAEs). To prevent fatality or chronicity, these irAEs are often promptly treated with high-dose immunosuppressants. Until recently, evidence on the effects of irAE management on ICI efficacy has been sparse. As a result, algorithms for irAE management are mostly expert-opinion based and barely consider poss…

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GEN - Genetic Engineering and Biotechnology News… broke the news in on Tuesday, July 8, 2025.
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