Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways

Nature

Center

Factuality

Ownership

Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways

Prenatal exposure to metals has been associated with impaired neurodevelopment in children, but the detailed molecular mechanisms remain largely unknown. Based on the Wuhan Healthy Baby Cohort, China (N = 1088), eleven metals were measured in maternal urine during early pregnancy (13.1 ± 1.1 weeks) and metabolomics profiling was conducted in cord blood. Neurodevelopment was evaluated using the Bayley Scales of Infant Development in 2-year-old ch…