Q&A: Team Discusses Uncovering ApoE3 Christchurch's Multi-Pathway Defense Against Alzheimer's

Q&A: Team discusses uncovering ApoE3 Christchurch's multi-pathway defense against Alzheimer's

Researchers have published a paper in Alzheimer's & Dementia, titled "ApoE3 Christchurch and tau interaction as a protective mechanism against Alzheimer's disease."

Alzheimer’s Risk Genes’ Pathways for Influencing Tau Spread in the Brain Mapped

Scientists have known for some time that Alzheimer’s disease affects brain regions differently. And they have a detailed understanding of how misfolded tau forms toxic tangles in the brain, impairing neuronal function. Typically, brain areas like the entorhinal cortex and hippocampus succumb early to tau tangles, while other areas, like the primary sensory cortices, remain resilient to the disease.  To better understand this observed selective v…