ADAM19 Knockdown Reduces Harmful Senescent Cell Signaling in Flies

ADAM19 Knockdown Reduces Harmful Senescent Cell Signaling in Flies

While much of the focus on cellular senescence in aging remains to find ways to selectively destroy these problem cells, there are also efforts to instead change their behavior. The reason why a growing burden of senescent cells in aged tissues is harmful, even when these cells make up only a tiny fraction of the overall cell population, is that they energetically secrete pro-inflammatory factors. This activity is disruptive to tissue structure …