A “toxic duo” may be the hidden trigger behind Alzheimer’s disease

A “toxic duo” may be the hidden trigger behind Alzheimer’s disease

Scientists have uncovered a toxic alliance between Aβ and fibrinogen that may explain how Alzheimer’s disease begins. The two proteins together create stubborn clots that damage blood vessels and spark inflammation in the brain. These effects appear even at very low concentrations and disrupt the blood-brain barrier, paving the way for neurodegeneration. The findings highlight a potential new therapeutic target for early intervention.