US EditionA Specific Form of cPRC1 Containing CBX4 is Co-opted to Mediate Oncogenic Gene Repression in Diffuse Midline Glioma
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A Specific Form of cPRC1 Containing CBX4 is Co-opted to Mediate Oncogenic Gene Repression in Diffuse Midline Glioma
Diffuse midline glioma (DMG) is a fatal childhood brain tumor characterized primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb repressive complex 2 (PRC2)-mediated H3K27 trimethylation (H3K27me3). Paradoxically, PRC2 is essential in DMG cells, although the downstream molecular mechanisms are poorly understood.
·Charlottesville, United States
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