US EditionA revolutionary drug for extreme hunger offers clues to obesity’s complexity
- In March 2025, the FDA authorized Vykat XR, a prolonged-release formulation of diazoxide choline, designed to alleviate persistent hunger in individuals with rare genetic obesity.
- The approval followed nearly six years of trials starting in 2018, prompted by the urgent need to treat hyperphagia in Prader-Willi syndrome patients like Dean Shenk.
- Dean, diagnosed as a baby, once endured uncontrollable hunger causing meltdowns and skin-picking tied to anxiety, but his symptoms improved significantly after treatment with Vykat XR.
- Soleno Therapeutics saw its stock soar 40%, valuing the company near $4 billion as many patients accept Vykat XR’s side effects for relief from hyperphagia’s devastating impact.
- Though not a cure, Vykat XR offers insights into obesity’s complexity but faces challenges as federal research funding declines and some FDA contacts depart.
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News Medical+15 Reposted by 15 other sources
A revolutionary drug for extreme hunger offers clues to obesity’s complexity
Ali Foley Shenk still remembers the panic when her 10-year-old son, Dean, finished a 20-ounce box of raisins in the seconds the cupboard was left unlocked. They rushed to the emergency room, fearing a dangerous bowel impaction.
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kffhealthnews.org+3 Reposted by 3 other sources
A Revolutionary Drug for Extreme Hunger Offers Clues to Obesity’s Complexity
Ali Foley Shenk still remembers the panic when her 10-year-old son, Dean, finished a 20-ounce box of raisins in the seconds the cupboard was left unlocked. They rushed to the emergency room, fearing a dangerous bowel impaction. The irony stung: When Dean was born, he was so weak and floppy he survived only with feeding tubes because he couldn’t suck or swallow. He was diagnosed as a baby with Prader-Willi syndrome — a rare disorder sparked by a …
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