A Multi-Kingdom Genetic Barcoding System for Precise Clone Isolation - Science in Vancouver
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A Multi-Kingdom Genetic Barcoding System for Precise Clone Isolation - Science in Vancouver
Cell-tagging strategies with DNA barcodes have enabled the analysis of clone size dynamics and clone-restricted transcriptomic landscapes in heterogeneous populations. However, isolating a target clone that displays a specific phenotype from a complex population remains challenging. Here we present a multi-kingdom genetic barcoding system, CloneSelect, which enables a target cell clone to be triggered to express a reporter gene for isolation thr…
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