A Mediterranean diet rich in vegetables, fish, and olive oil reduces dementia risk even in people carrying two copies of the APOE4 gene variant — which raises Alzheimer's risk 12-fold — according to a 2025 Harvard study in Nature Medicine, in the first finding that a daily food pattern can partially overcome a genetic predisposition long thought to be inescapable

A Mediterranean diet rich in vegetables, fish, and olive oil reduces dementia risk even in people carrying two copies of the APOE4 gene variant — which raises Alzheimer's risk 12-fold — according to a 2025 Harvard study in Nature Medicine, in the first finding that a daily food pattern can partially overcome a genetic predisposition long thought to be inescapable

For people who carry two copies of the APOE4 gene, the message from clinical medicine over the past three decades has been blunt: your risk of developing Alzheimer’s disease is dramatically elevated, the elevation is genetic, and there is not much you can do about it. About 2 percent of the human population falls into this category. They have inherited one copy of the APOE4 variant from each parent, which combine to produce a 12-fold higher life…