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Top Broad Institute News

Bayer and Broad Institute Extend Research Collaboration to Develop New Cardiovascular Therapies
Cambridge, Massachusetts · Cambridge

Bayer and Broad Institute Extend Research Collaboration to Develop New Cardiovascular Therapies

100% Center coverage: 1 sources
BERLIN & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 11, 2025-See the Story
Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases
Cambridge, Massachusetts · Cambridge

Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases

Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases By Leah Eisenstadt June 24, 2025 Breadcrumb Home Q&A: One scientist’s bold vision to make on-demand treatments routine for life-threatening rare genetic diseases Broad core member and gene editing pioneer David Liu describes a framework that could enable the treatment of 1,000 patients with personalized gene editing therapies by …Read Article

New technique expands cells to sequence DNA and capture fine structural details

New technique expands cells to sequence DNA and capture fine structural details By Allessandra DiCorato May 29, 2025 Breadcrumb Home New technique expands cells to sequence DNA and capture fine structural details Using this method, scientists discovered key protein and gene activity changes in aging and in a rare disease called progeria. By Allessandra DiCorato May 29, 2025 Credit: Buenrostro lab Example of expansion in situ genome sequen…DNA · CambridgeRead Article

Novel Glycopeptide Antibiotic Candidate Shows Promise

Researchers have discovered a new type of glycopeptide antibiotic known as saarvienin A, found to have strong activity against highly resistant bacterial strains.See the Story

Gene editing disrupts Huntington’s mutation in mice

Gene editing disrupts Huntington’s mutation in mice By Allessandra DiCorato May 27, 2025 Breadcrumb Home Gene editing disrupts Huntington’s mutation in mice Making single-letter edits in stretches of repeated DNA stopped or reversed the genetic change that causes Huntington’s disease and Friedreich’s ataxia. By Allessandra DiCorato May 27, 2025 Credit: Agnieszka Grosso, Broad Communications Related news More versatile and efficient base …DNA · CambridgeRead Article

AI-Powered Gene Vectors Offer Cell-by-Cell Access to Brain and Spinal Cord

100% Center coverage: 3 sources
Neuroscience · United StatesSee the Story

Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder

Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder By Leah Eisenstadt May 20, 2025 Breadcrumb Home Scientists build cell line atlas of deadly cancers of the bile ducts and gallbladder Researchers reveal new subtypes and potential therapeutic targets for biliary tract cancers, which lack effective treatments. By Leah Eisenstadt May 20, 2025 Credit: Susanna Hamilton, Broad Communications Related groups Bro…Cambridge, Massachusetts · CambridgeRead Article

Aging Metabolism Reduces Effectiveness of CAR-T Cell Therapy

100% Center coverage: 3 sources
A Ludwig Cancer Research study has discovered that the metabolic decline that accompanies aging impairs the efficacy of CAR-T cell therapy, an immunotherapy in which T cells of the immune system are taken from patients, engineered to target cancer cells and reinfused into the same patients for treatment.CancerSee the Story

The Human Genetics of Anorexia Nervosa

Anorexia nervosa is a severe eating disorder characterised by restricted eating, the relentless pursuit of thinness and obsessive fears of being fat. …DNA · CambridgeSee the Story

Cas9 Ancestor Engineered Into a Compact Genome Editing Tool

100% Center coverage: 2 sources
Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The engineered protein, called NovaIscB, can be adapted to make precise changes to the genetic code, modulate the activity of specific genes, or carry out other editing tasks. Because its small size simplifies delivery to cells, NovaIscB's develop…Harvard · CambridgeSee the Story

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