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Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs

  • On May 11, 2025, Eli Lilly announced that their Phase 3b SURMOUNT-5 trial showed Zepbound outperformed Wegovy for weight loss in adults with obesity or overweight in the U.S. And Puerto Rico.
  • The trial included 751 adults without diabetes but with obesity or overweight plus at least one weight-related condition, and aimed to prove Zepbound's superiority in percent body weight change at 72 weeks.
  • Participants on Zepbound lost 20.2% of their body weight and reduced waist circumference by 18.4 cm, exceeding Wegovy's 13.7% weight loss and 13.0 cm waist reduction, with mostly mild to moderate gastrointestinal side effects.
  • Leonard Glass from Lilly noted that, in the SURMOUNT-5 trial, Zepbound achieved substantially greater weight loss than Wegovy in all measured outcomes, reinforcing its position as a top treatment option for individuals with obesity.
  • The results suggest Zepbound may become a preferred therapy for obesity, though safety comparisons were not powered and treatment decisions should involve healthcare providers considering individual risks.
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Zepbound Outperforms Wegovy in Head-to-Head Weight Loss Study

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WGN 9 broke the news in Chicago, United States on Sunday, May 11, 2025.
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