Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs
- On May 11, 2025, Eli Lilly announced that their Phase 3b SURMOUNT-5 trial showed Zepbound outperformed Wegovy for weight loss in adults with obesity or overweight in the U.S. And Puerto Rico.
- The trial included 751 adults without diabetes but with obesity or overweight plus at least one weight-related condition, and aimed to prove Zepbound's superiority in percent body weight change at 72 weeks.
- Participants on Zepbound lost 20.2% of their body weight and reduced waist circumference by 18.4 cm, exceeding Wegovy's 13.7% weight loss and 13.0 cm waist reduction, with mostly mild to moderate gastrointestinal side effects.
- Leonard Glass from Lilly noted that, in the SURMOUNT-5 trial, Zepbound achieved substantially greater weight loss than Wegovy in all measured outcomes, reinforcing its position as a top treatment option for individuals with obesity.
- The results suggest Zepbound may become a preferred therapy for obesity, though safety comparisons were not powered and treatment decisions should involve healthcare providers considering individual risks.
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Battle of the weight loss blockbuster drugs: Zepbound beats Wegovy by nearly 50%
Participants who took tirzepatide — which is sold as Zepbound by Eli Lilly — lost an average of 50 pounds over 72 weeks. Those who took semaglutide — known as Novo Nordisk's Wegovy, lost about 33 pounds.
·Michigan, United States
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