Why older mice have smaller offspring-and how sex may play a role

Why older mice have smaller offspring-and how sex may play a role

6.11.2025 - A study by University of Manchester scientists has revealed some of the mechanisms which may explain why older mice are more likely to give birth to offspring that have not grown to their full potential in the womb.

Why older mice have smaller offspring—and how sex may play a role

A study by University of Manchester scientists has revealed some of the mechanisms which may explain why older mice are more likely to give birth to offspring that have not grown to their full potential in the womb. The study in older animals  showed that the placentas of male but not female offspring had increased cell damage from a biological state called oxidative stress. Oxidative stress occurs when harmful molecules called free radicals bui…