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WHO Issues First Guidelines for GLP-1 Obesity Treatments

WHO's guideline urges combining GLP-1 therapies with lifestyle counseling for obesity, noting less than 10% of patients may access treatment by 2030 due to limited supply and costs.

  • On Monday, the World Health Organization recommended GLP-1 drugs as a tool to manage obesity in adults, publishing guidance in JAMA defining long-term use as six months or more.
  • Regulatory approvals, including by the Food and Drug Administration, preceded the guidance drafted by a committee of obesity, pharmacology and public-health experts at the request of WHO member states amid debate in recent years.
  • GLP-1 drugs work by mimicking a hormone that signals fullness and reduce appetite to help people lose weight, while more than 890 million adults worldwide are obese and obesity causes 3.7 million deaths annually.
  • The recommendation is conditional, the WHO said, as benefits likely outweigh downsides but more long-term safety and efficacy data, plus lower prices, are needed to address access and pricing concerns.
  • In the U.S., one in eight adults report currently taking a GLP-1 drug amid the societal shift in obesity framing and WHO urging public-health coordination.
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128 Articles

Lean Left

GLP-1-type consumer drugs can be used in long-term therapy, but access remains a problem.

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Center

The WHO has published its first guideline on the use of so-called weight loss shots against obesity.

·Germany
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JAMA Network broke the news in on Monday, December 1, 2025.
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