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Which ‘Grey’s Anatomy’ Characters Do You Want to Return for Season 22? (POLL)

  • Season 22 of Grey's Anatomy, arriving this fall, will follow up on a massive gas explosion in the Season 21 finale at Seattle Grace Hospital's surgical wing.
  • The explosion's casualties remain unknown, leading to speculation about which characters, including some longtime absentees, might return for updates this season.
  • Several original characters like Alex Karev, Izzie Stevens, Callie Torres, Penelope Blake, and Erica Hahn, all still alive in canon, are potential candidates for comebacks, with Sandra Oh reportedly open to reprising Cristina Yang.
  • Justin Chambers played Alex Karev, Katherine Heigl played Izzie Stevens, Sara Ramirez portrayed Callie Torres, and Samantha Sloyan and Brooke Smith played Penelope Blake and Erica Hahn respectively, confirming their established roles.
  • These possible returns and references to prior character resurrections suggest that Season 22 may include notable surprise appearances and continue exploring fates of departed characters.
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Which ‘Grey’s Anatomy’ Characters Do You Want to Return for Season 22? (POLL)

From long gone series originals to memorable patients, and more, there are a ton of options.

·Cherokee County, United States
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  • 34% of the sources are Center, 34% of the sources lean Right
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KULR-TV broke the news in Billings, United States on Sunday, June 1, 2025.
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