US EditionUSC Study Finds Stroke Survivors' Undamaged Brain Regions Appear 'Younger'
AI analysis of MRI data from over 500 stroke survivors shows severe strokes accelerate aging in damaged brain hemispheres while the opposite side shows compensatory structural rejuvenation.
- Scientists at Stevens INI discovered in The Lancet Digital Health that undamaged brain regions may 'rejuvenate' following severe strokes, showing unexpected structural changes as the brain adapts to injury.
- Paradoxically, while stroke damage accelerates aging in the injured hemisphere, the brain makes the undamaged side appear 'younger' to compensate for lost motor function.
- Analyzing MRI scans from over 500 survivors, the ENIGMA Stroke Recovery Working Group detected subtle patterns of brain reorganization across eight countries, building the world's largest stroke neuroimaging dataset.
- Survivors with severe movement deficits showed the most 'youthful' structural patterns in the frontoparietal network, a key system for motor planning, attention, and coordination, even after more than six months of rehabilitation.
- Hosung Kim, PhD, associate professor of research neurology at the Keck School of Medicine of USC, described this as the brain's way of 'retooling' healthy networks to compensate for damaged motor systems.
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University of Southern CaliforniaUSC study identifies brain rewiring mechanism that may aid stroke recovery
In a new study published in The Lancet Digital Health, scientists at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute have discovered that the brains of people who experience severe physical impairment after a stroke may reorganize themselves in unexpected ways, showing signs of “younger” brain structure in undamaged regions as they adapt to injury. The international research effort is part of the Enhanc…
Severe strokes may 'rejuvenate' undamaged brain regions
In a new study published in The Lancet Digital Health, scientists at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) have discovered that the brains of people who experience severe physical impairment after a stroke may reorganize themselves in unexpected ways, showing signs of "younger" brain structure in undamaged regions as they adapt to injury.
Stroke may trigger younger brain patterns in unaffected regions
In a new study published in The Lancet Digital Health, scientists at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) have discovered that the brains of people who experience severe physical impairment after a stroke may reorganize themselves in unexpected ways, showing signs of "younger" brain structure in undamaged regions as they adapt to injury.
ENIGMA Study Reveals Contralesional Brain Rejuvenation
Researchers from USC and the ENIGMA Stroke Recovery Working Group published in The Lancet Digital Health report that deep-learning analysis of MRI scans from over 500 stroke survivors across 34 sites in eight countries found the undamaged hemisphere can appear structurally 'younger' while the damaged side shows accelerated aging. Using graph convolutional networks to estimate regional brain-PAD, they found contralesional rejuvenation in frontopa…
Stroke Survivors’ Brains Rejuvenate to Compensate for Injury
AI analysis of 500 stroke survivors reveals that the brain compensates for severe injury by "rejuvenating" undamaged regions. While the stroke site ages faster, the opposite side of the brain develops a "younger" structure to support motor planning.
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