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Understanding the impact of spray drying temperature on the dissolution behavior of a HPMC-AS spray dried formulation
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Understanding the impact of spray drying temperature on the dissolution behavior of a HPMC-AS spray dried formulation
Abstract Spray dried dispersion (SDD) is increasingly used in solid dose formulations for poorly soluble active pharmaceutical ingredients (APIs). Dissolution was studied on a HPMC-AS based SDD and one important SDD manufacturing parameter, the spray drying outlet temperature (Tout), was found to significantly affect the dissolution rate of the tablet formulation containing the SDD. The dissolution rate of tablets containing SDD made at higher T…
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