Deciphering Genetic Causes for Sex Differences in Human Health Through Drug Metabolism and Transporter Genes

Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes

Sex differences have been widely observed in human health. However, little is known about the underlying mechanism behind these observed sex differences. We hypothesize that sex-differentiated genetic effects are contributors of these phenotypic differences. Focusing on a collection of drug metabolism enzymes and transporters (DMET) genes, we discover sex-differentiated genetic regulatory mechanisms between these genes and human complex traits. …

Two-faced gene variant appears good for men, bad for women

Heart experts at Cincinnati Children's make a sex-dependent genetic discovery that could help some men reduce their risk of diabetes and explain why some women face a higher risk of artery disease