Tramadol And Antidepressants Raise Seizure Risk

Tramadol and Antidepressant Interactions May Increase Seizure Risks: Study

Certain antidepressants can interfere with how the body processes the opioid painkiller Tramadol, potentially altering its effectiveness and increasing the risk of side effects. A new study suggests that taking the painkiller Tramadol with certain antidepressants, including Paxil and Prozac, may increase the likelihood of convulsions among nursing home reside…

Tramadol And Antidepressants Raise Seizure Risk

In a Medicare nursing home cohort, tramadol with CYP2D6-inhibiting antidepressants was linked to higher seizure rates than CYP2D6-neutral agents, supporting cautious co-prescribing in older adults.