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Ancient Anesthetic Reveals Ming China's Sophisticated Medicine

Researchers say residue on 600-year-old tools shows Ming Dynasty surgeons used aconitine, a toxic plant compound, to numb patients before minor operations.

  • On Tuesday, researchers published findings in Antiquity revealing that iron scissors and tweezers from a Ming Dynasty surgeon's tomb in Jiangyin, roughly 90 miles northwest of Shanghai, contain residue of aconitine, marking the first direct chemical evidence of surgical anesthesia on ancient tools.
  • The implements were excavated in 1974 but remained unanalyzed for fifty years until researchers gained access to advanced spectroscopy techniques; housed in Jiangyin Museum, the tools' difficult-to-clean crevices near handles preserved residues protected from contamination.
  • Using micro-Raman spectroscopy, researchers identified three tiny particles of aconitine derived from Aconitum carmichaelii , native to North America, Europe and Asia. Congcang Zhao of Northwest University notes stimulated Raman scattering imaging overcame challenges in analyzing minimal samples while preserving artifacts.
  • The 600-year-old implements likely served minor surgeries, with anesthetic residue concentrated on functional areas consistent with topical application. Zhao states the discovery confirms Ming Dynasty medical texts documenting aconitine's use as a precisely applied topical anesthetic with strict procedural controls.
  • Ming practitioners employed sophisticated detoxification methods including treatment with young boys' urine, vinegar boiling, and black soybean decoction. Carney Matheson of Griffith University calls this 'the earliest direct evidence of anaesthetics,' suggesting early surgeons possessed more medical knowledge about pain reduction than previously credited.
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According to writing sources, Chinese physicians once made a narcotic out of highly toxic iron hat. Now, experts have discovered a direct proof of this.

·Heidelberg, Germany
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Phys.org broke the news in United Kingdom on Monday, May 25, 2026.
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