Detroit scored five times in the sixth and added two seventh-inning homers to give Jack Flaherty his second quality start of the season.
On Friday, the Detroit Tigers defeated the Philadelphia Phillies 10-2 at Comerica Park, marking their sixth straight victory before a crowd of 34,084.
Jack Flaherty limited the Phillies to two runs over six innings, earning his third win in six starts with defensive support from All-Star left fielder Riley Greene.
Detroit broke a 2-2 tie in the sixth inning with a five-run rally, sparked by rookie Eduardo Valencia's go-ahead RBI single and a two-run triple from James Outman.
Colt Keith and Spencer Torkelson each homered in the seventh inning, extending the Tigers' lead into double digits and securing the decisive victory.
The teams continue their three-game series on Saturday, with Tigers RHP Casey Mize facing All-Star RHP Cristopher in the second game at Detroit.