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The Sulfoximine Group: A Rising Star in Medicinal Chemistry

Summary by Drug Hunter
Sulfoximines are versatile functional groups that can offer opportunities for improving the physicochemical and ADME properties of drug candidates. In this article, we present key synthetic routes for the introduction of sulfoximine motifs and showcase real-world case studies where scientists have leveraged sulfoximine groups as bioisosteres of sulfones and sulfonamides. We also discuss the wide application of sulfoximine functional groups in co…
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Drug HunterDrug Hunter

The Sulfoximine Group: A Rising Star in Medicinal Chemistry

Sulfoximines are versatile functional groups that can offer opportunities for improving the physicochemical and ADME properties of drug candidates. In this article, we present key synthetic routes for the introduction of sulfoximine motifs and showcase real-world case studies where scientists have leveraged sulfoximine groups as bioisosteres of sulfones and sulfonamides. We also discuss the wide application of sulfoximine functional groups in co…

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Drug Hunter broke the news in on Wednesday, June 4, 2025.
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