US EditionThe Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance
Their discoveries on regulatory T cells launched a new immunology field and spurred over 200 clinical trials for cancer and autoimmune disease treatments, Nobel Committee said.
- The Nobel Assembly at Karolinska Institute, Stockholm, Sweden, awarded the 2025 Nobel Prize in Physiology or Medicine jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi on Monday .
- Sakaguchi's early work in the 1990s showed he discovered regulatory T cells in 1995, while Brunkow and Ramsdell identified the Foxp3 mutation linked to autoimmune disease in 2001.
- Their papers showed that CD4+CD25+FOXP3+ regulatory T cells act as the immune system's security guards, and `The laureates’ discoveries launched the field of peripheral tolerance, spurring the development of medical treatments for cancer and autoimmune diseases` .
- Clinical researchers now run more than 200 clinical trials testing regulatory T cell therapies, and the trio will share the prize purse of 11 million Swedish kronor .
- Medicine traditionally begins Nobel week, with their work opening new possibilities for autoimmune disease and cancer research, while physics, chemistry, and literature winners follow this week.
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The Nobel Prize in Medicine or Physiology 2025 went to Americans Mary E. Brunkow and Fred Ramsdell and Japanese Shimon Sakaguchi for revealing how the immune system is self-regulating, that is, “for its discoveries related to peripheral immune tolerance.” The Nobel Assembly of the Karolinska Institute in Stockholm explained that the winners identified immune system security guards, regulatory T cells, which prevent immune cells from attacking ou…
Scientists win 2025 Nobel Prize in Medicine for immune system discoveries
Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for discovering how the immune system learns to tolerate the body’s own cells, according to the Nobel Assembly at Karolinska Institutet. The award was announced on Monday in Stockholm, Sweden. The Nobel Committee said the three scientists uncovered how the body prevents its powerful immune system from attacking its own organs, a …
How does your immune system stay balanced? A Nobel Prize-winning answer
Regulatory T cells (red) interact with other immune cells (blue) and modulate immune responses. National Institute of Allergy and Infectious Diseases/NIH via FlickrEvery day, your immune system performs a delicate balancing act, defending you from thousands of pathogens that cause disease while sparing your body’s own healthy cells. This careful equilibrium is so seamless that most people don’t think about it until something goes wrong. Autoimmu…
Trio of Researchers Awarded Nobel Prize for Groundbreaking Discovery of Immune Cells That Prevent Autoimmune Disease
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi’s research revealed a new class of cells shaking up scientists’ understanding of the human immune system
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