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The key to cancer care? It may be a healthy gut, according to new research
Nearly 100 studies are testing probiotics, high-fiber diets and fecal transplants as doctors seek to improve immunotherapy and prevent transplant complications.
- In the coming days, University Hospitals Seidman Cancer Center in Cleveland will enroll the first participant in a late-phase trial testing CBM588, a probiotic bacterial strain, to amplify immunotherapy for advanced renal cell carcinoma.
- Cancer research has increasingly focused on the gut microbiome after studies confirmed its critical role in immune function and treatment efficacy. The microbiome appears especially important for immunotherapy, which relies on medications that manipulate the body's own immune system to attack cancer.
- The American Society of Clinical Oncology lists nearly 100 recent or ongoing studies testing various ways to manipulate the gut microbiome to help treat cancer, ranging from synthetic fecal transplants to dietary coaching and probiotics.
- Clinicians now practice greater antibiotic stewardship to preserve patient microbiomes, while City of Hope Cancer Center in Duarte has changed its inpatient food menu and planted a garden where patients can access fresh vegetables.
- Experts emphasize the need for rigorous clinical data before widespread adoption of microbiome therapies. Dr. Marcel van den Brink, president of City of Hope Cancer Center, said, "We're only just starting to learn how to manipulate it.
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