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Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases

Summary by Nature
Pathogenic gene dysregulation can be attributed to chromatin state change that pre-transcriptionally regulates expression. Recent breakthroughs elucidating the rules governing this DNA control layer, an epigenetic code, unlock a modality in precision medicine to target gene dysregulation across myriad diseases. Here we present a modular platform to design programmable mRNA therapeutics, Epigenomic Controllers (EC), that control gene expression t…

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Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases

Pathogenic gene dysregulation can be attributed to chromatin state change that pre-transcriptionally regulates expression. Recent breakthroughs elucidating the rules governing this DNA control layer, an epigenetic code, unlock a modality in precision medicine to target gene dysregulation across myriad diseases. Here we present a modular platform to design programmable mRNA therapeutics, Epigenomic Controllers (EC), that control gene expression t…

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celiac.comceliac.com

The Future of Celiac Disease Treatment: mRNA Vaccines at Penn's Institute for RNA Innovation (+Video)

Celiac.com 03/17/2025 - For millions of people with celiac disease, consuming gluten can trigger severe digestive distress, long-term intestinal damage, and an increased risk of serious health conditions. The only current treatment is a strict gluten-free diet, which can be challenging and stressful to maintain. However, scientists at Penn’s Institute for RNA Innovation are exploring a groundbreaking approach using messenger RNA (mRNA) technolog…

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celiac.com broke the news in on Monday, March 17, 2025.
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