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The drug used in Tennessee’s failed execution has come under past scrutiny
Governor Bill Lee ordered a third-party review after the first known pentobarbital execution failure and said no other Tennessee execution will occur this year.
On Wednesday, Tennessee's attempt to execute Christa Pike failed after two doses of pentobarbital were administered; officials have not explained the malfunction, and it remained unclear on Thursday whether Pike was still alive.
President Donald Trump resumed federal executions during his first term, adopting pentobarbital to replace older three-drug protocols, and the Justice Department reauthorized the drug's use in 2026 after his return to power.
Tennessee's guidelines require a 5 gram dose of pentobarbital; experts cited in a 2025 federal review warned the drug may cause pulmonary edema, creating a sensation of suffocating before unconsciousness occurs.
Republican Gov. Bill Lee ordered a third-party review of the failed execution and announced that no further executions will take place in Tennessee this year.
Other states including South Carolina, Georgia, and Texas utilize pentobarbital with varying protocols; however, a 2025 federal review concluded, "there remains significant uncertainty about whether the use of pentobarbital as a single drug lethal injection causes unnecessary pain and suffering.