CRISPR Technologies and the Search for the PAM-Free Nuclease

CRISPR technologies and the search for the PAM-free nuclease

The ever-expanding set of CRISPR technologies and their programmable RNA-guided nucleases exhibit remarkable flexibility in DNA targeting. However, this flexibility comes with an ever-present constraint: the requirement for a protospacer adjacent motif (PAM) flanking each target. While PAMs play an essential role in self/nonself discrimination by CRISPR-Cas immune systems, this constraint has launched a far-reaching expedition for nucleases with…

The Download: funding a CRISPR embryo startup, and bad news for clean cement

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Crypto billionaire Brian Armstrong is ready to invest in CRISPR baby tech Brian Armstrong, the billionaire CEO of the cryptocurrency exchange Coinbase, says he’s ready to fund a US startup focused on gene-editing human embryos. If he goes forward, it would be the first major commercial investment in one of med…