US EditionThe Billion-Year Rules Governing Protein Stability
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How did evolution choose the handful of amino acid combinations that allow proteins to fold, stay stable, and do their work? And can we learn these rules to help protein engineers design better drugs or more ecological catalysts? A study published in Science magazine has taken an important step to answer both questions. Proteins have a core that prevents the structure from collapsing, while the surface does most of the work. For decades, biologi…
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