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Tessera Therapeutics Announces FDA Clearance of IND Application for its Lead In Vivo Gene Editing Program TSRA-196 for AATD

“This is exciting news for the Alpha-1 community, marking an important regulatory milestone for Tessera Therapeutics and also, in the field of in vivo genome editing. ​ It is the first-ever IND clearance for a therapy based on target-primed reverse transcription (TPRT)-based genome editing. ​ This approval allows Tessera to initiate its Phase 1/2 clinical trial, bringing the company closer to delivering an innovative therapy designed to permanen…
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Alpha-1 Foundation broke the news in on Friday, January 16, 2026.
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