Recurrent Somatic Mutation and Progerin Expression in Early Vascular Aging of Chronic Kidney Disease

Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease

Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well understood. Here we found progerin, the protein responsible for the premature aging disease Hutchinson–Gilford progeria syndrome, steadily recurring in vascular smooth muscle cells of patients with CKD. Notably, th…

Telomir Pharmaceuticals Prevents Cellular Aging in Patient-Derived Cells from Children with Progeria - an Ultra-Rare Genetic Disorder that Causes Rapid Aging

Study used cell lines obtained from the Progeria Research Foundation to evaluate Telomir-1's effects on key drivers of accelerated aging

EXCLUSIVE: Telomir Pharmaceuticals Says Preclinical Drug Candidate Prevents Premature Aging In Patient-Derived Cells From Children With Progeria - Telomir Pharmaceuticals (NASDAQ:TELO)

Telomir-1 improved cell survival, reduced oxidative stress, and restored mitochondrial balance in preclinical progeria study.

Telomir’s lead candidate prevents cellular aging in patient-derived cells from children with Progeria - BioTuesdays

Telomir Pharmaceuticals (NASDAQ: TELO) announced new preclinical data showing that Telomir-1 prevented cellular aging in patient-derived cells from children with progeria—Hutchinson-Gilford Progeria Syndrome (HGPS)—an ultra-rare pediatric disorder that causes rapid biological aging in children. Telomir-1 is designed to regulate intracellular metal ions, reduce oxidative stress, restore mitochondrial function, extend telomere length, reverse musc…