Fighting Kidney Disease by Targeting Neutrophils

Fighting kidney disease by targeting neutrophils

When harmful bacteria or other microorganisms invade the body, neutrophils, a type of white blood cell, are one of the first immune cells to respond. They release powerful weapons to trap and kill these threats, one of the most important being neutrophil extracellular traps, or NETs. These are web-like structures made from DNA and proteins that act like sticky nets, trapping microbes and preventing them from spreading.

JCI PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung

Neutrophils are the most abundant immune cells that constantly patrol or marginate inside vascular beds to support immune homeostasis. The extent to which neutrophils undergo reprogramming in response to the changes in vascular architecture and the resultant biological implications of such adaptations remain unclear. Here, we performed intravital imaging and transcriptional profiling to investigate neutrophil behavior across different tissues. O…

Targeting Neutrophils: A New Strategy to Combat Kidney Disease

In the intricate realm of human immunity, neutrophils stand as frontline warriors, deploying an arsenal of mechanisms to counter invading pathogens. Among their most remarkable defenses is the formation of neutrophil extracellular traps, or NETs—complex networks composed primarily of decondensed chromatin and antimicrobial proteins. These DNA-based webs extend into the extracellular space, physically ensnaring bacteria, fungi, and other harmful …

Join the Fight Against Alzheimer’s Disease at the “Making Memories” Golf Classic

The “Making Memories” Golf Classic is an impactful event aimed at raising awareness and funds to combat Alzheimer’s disease. By participating in this golf classic, you become an essential part of the movement to eradicate this devastating condition. Your involvement not only enhances the event but also contributes significantly to the ongoing fight against Alzheimer’s.

Three-Dimensionally Reconstructed Kidney Glomerulus Simulates Structural and Functional Characteristics In Vitro

A 3D engineered kidney glomerulus model replicates structural and mechanical features of the glomerular filtration barrier, enabling the study of podocyte-related diseases and drug screening with improved physiological relevance.