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Targeting 17β-HSD13: Emerging Patent Landscape in Fibrosis and NASH

Summary by Drug Hunter
17β-HSD13 is a member of a 15-enzyme family involved in the metabolism of steroid hormones, fatty acids, cholesterol, and bile acids. It is a promising target for NAFLD and NASH, supported by GWAS data showing that loss-of-function variants reduce liver enzyme levels and disease risk. Clinical validation came from Arrowhead’s ARO-HSD, an siRNA that lowered serum ALT. While the full function of 17β-HSD13 remains unclear, it acts on lipid substrat…
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Drug Hunter broke the news in on Tuesday, July 1, 2025.
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