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Tabletability Flip in Dry Granulated Systems
Summary by Pharma Excipients
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Tabletability Flip in Dry Granulated Systems
Abstract Purposes The tabletability flip phenomenon (TFP), where an active pharmaceutical ingredient (API) with poorer tabletability exhibits better tabletability when formulated with excipients, has been well documented in direct compression systems. However, the impact of granulation on TFP remains unexplored. Hence, the purpose of this work was to investigate the occurrence and underlying mechanisms of TFP in dry-granulated formulations. Meth…
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