Mitochondria found to fuel dangerous growth in aging blood stem cells

Exosome regulation by Rubicon in ageing

Autophagy decreases with age, and this is in part attributed to increasing levels of the autophagy-suppressing protein Rubicon. Cell biologists now find another ageing-associated function for Rubicon — the release of exosomes containing microRNAs that control senescence and longevity.

Mitochondria found to fuel dangerous growth in aging blood stem cells

As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations.

Supercharged mitochondria spark aging-related blood disorders

As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations. These mutations can give the cells a growth advantage, laying the foundation for developing serious health conditions. Now, scientists at The Jackson Laboratory (JAX) have not only discovered the mechanism that fuels their unchecked growth but have also found a way to stop it.

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Supercharged Mitochondria Drive Aging-Linked Blood Disorders

In a groundbreaking study that elegantly unravels the intricate relationship between genetic mutations and cellular metabolism, researchers at The Jackson Laboratory have illuminated a novel mechanism by which age-related mutations substantially enhance the proliferative capabilities of blood stem cells. This revelation not only deepens our understanding of how aging primes the body for hematologic disorders but also offers a vivid glimpse into …