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Reactive Oxidative Species May Play Key Role in Some Chemotherapy Resistance

Summary by Inside Precision Medicine
The cause of chemotherapy resistance is one of the biggest questions in cancer but has proven difficult to address. Now, researchers have found that mutations to VPS35, a key player in the reactive oxygen species (ROS) pathway, can prevent chemotherapy-induced cell death. Specifically, the researchers identified cysteines, a member of the retromer trafficking complex. These results, they suggest, could help pinpoint treatment-resistant tumors.  …
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Inside Precision MedicineInside Precision Medicine

Reactive Oxidative Species May Play Key Role in Some Chemotherapy Resistance

The cause of chemotherapy resistance is one of the biggest questions in cancer but has proven difficult to address. Now, researchers have found that mutations to VPS35, a key player in the reactive oxygen species (ROS) pathway, can prevent chemotherapy-induced cell death. Specifically, the researchers identified cysteines, a member of the retromer trafficking complex. These results, they suggest, could help pinpoint treatment-resistant tumors.  …

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GeneOnline NewsGeneOnline News

Study Links VPS35 Mutations to Chemotherapy Resistance in Certain Cancers

**Study Links VPS35 Mutations to Chemotherapy Resistanc […] The post Study Links VPS35 Mutations to Chemotherapy Resistance in Certain Cancers first appeared on GeneOnline News. The post Study Links VPS35 Mutations to Chemotherapy Resistance in Certain Cancers appeared first on GeneOnline News.

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GeneOnline News broke the news in on Sunday, March 30, 2025.
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