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Study identifies PDGFRA as a potential target for pediatric high-grade gliomas

Summary by News Medical
Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

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Study identifies PDGFRA as a potential target for pediatric high-grade gliomas

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis.

·United States
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Inside Precision MedicineInside Precision Medicine

Promising New Target for High-Grade Pediatric Gliomas

Platelet-derived growth factor receptor alpha (PDGFRA) is a potential new drug target for pediatric high-grade gliomas, according to research from Dana Farber and collaborators. The team also provided the first real-world clinical data to support the use of a PDGFRA inhibitor in the treatment of certain pediatric patients with high-grade gliomas. The research was published in Cancer Cell, and the lead author is Dana Farber’s Lisa Mayer, MD. The …

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News Medical broke the news in United States on Thursday, March 27, 2025.
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