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Study Finds Marijuana May Cause Chromosomal Defects in Eggs

  • Cyntia Duval and colleagues published a study on September 9 in Nature Communications linking THC exposure to chromosomal abnormalities in eggs from women undergoing IVF in Toronto.
  • The study addressed a knowledge gap about cannabis effects on female fertility, motivated by data on male fertility and pregnancy and Canada’s 2018 cannabis legalization.
  • Researchers analyzed 1,059 follicular fluid samples, found THC in 62, and showed that THC disrupted chromosome sorting in immature eggs, likely affecting fertility.
  • Lab results showed THC exposure increased aneuploidy by 9% and spindle abnormalities more than doubled, while 60% of embryos in THC-positive samples had normal chromosomes versus 67% of THC-negative.
  • Authors cautioned the findings show association, not causation, may not generalize beyond IVF patients, and advised avoiding or reducing cannabis use when trying to conceive.
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According to recent research, marijuana can damage oocytes (unfertilized eggs in a woman's ovaries). Researchers fear it can cause infertility, miscarriage, and possible genetic defects in babies.

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La Vanguardia broke the news in Granada, Spain on Tuesday, September 9, 2025.
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