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Study: Daily Multivitamin Slows Biological Aging

  • A randomized COSMOS analysis published Monday showed daily multivitamins were associated with about four months' less biological aging over two years, based on 958 participants with an average age around 70.
  • Researchers used five epigenetic clocks including second-generation models to analyse DNA methylation biomarkers in blood samples from the COSMOS trial randomization into four pill groups.
  • Measured by specific clocks, PCPhenoAge slowed aging by about 2.6 months and PCGrimAge by about 1.4 months, while participants with accelerated biological age at baseline saw PCGrimAge slow by about 2.8 months.
  • Experts caution that effect sizes are modest, and Sesso said, 'Rather, this is starting to provide the connecting dots', advising decisions be made with healthcare providers.
  • Researchers plan follow-up analyses to see whether clock changes persist and link to clinical outcomes such as cognition, cancer or cataracts, Yanbin Dong, MD, Ph.D., said; if validated, daily multivitamins could be a cost-efficient intervention with small cancer-risk reductions over 10 years.
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Similarly, there is a need to consider diet, lifestyle and medical advice as a whole before deciding on the use of vitamin supplements.

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Nature broke the news in United Kingdom on Monday, March 9, 2026.
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