Stem Cell Culture Conditions Affect In Vitro Differentiation Potential and Mouse Gastruloid Formation

A study led by Acaimo González Reyes, from the Andalusian Center for Development Biology (CABD) – a mixed center of the Higher Council for Scientific Research (CSIC), the Pablo de Olavide University in Seville, and the Junta de Andalucía – and Federico Zurita, from the University of Granada, describes for the first time the aging mechanisms of the cells that make up a niche of stem cells. The study has had the collaboration of the Manuel Irimia …

Stem Cell Culture Conditions Affect In Vitro Differentiation Potential and Mouse Gastruloid Formation

When researchers investigated the cell type composition of gastruloids grown from different pre-cultures, they observed that mESCs subjected to 2i-ESLIF preceding aggregation generated gastruloids more consistently, including more complex mesodermal contributions than the ESLIF-only control. [PLOS One] Full Article