Smurf1 promotes gastric cancer growth and metastasis by regulating Axin2- dependent Wnt/β-catenin signaling

Solid tumour CAR T-cell therapy achieves PFS gain in gastric cancer

By Lynda Williams, medwireNews ReportermedwireNews: The first randomised controlled trial of a CAR T-cell therapy in solid tumours has achieved a significant improvement in progression-free survival for patients with advanced gastric or gastro-oesophageal junction cancer compared with physician’s choice of therapy.This independent news story was supported by an educational grant from L’Institut Servier, Suresnes, France.Read the full story on th…

Smurf1 promotes gastric cancer growth and metastasis by regulating Axin2- dependent Wnt/β-catenin signaling

SMAD-specific E3 ubiquitin protein ligase 1 (Smurf1) is involved in various biological processes through targeting specific proteins for ubiquitin-dependent degradation. Emerging evidence has shown that Smurf1 functions as an oncogene in many types of human tumours, including gastric cancer (G...