Scientists Discover a Protein that Protects the Brain From Alzheimer’s Damage
Boosting SORLA in mice reduced tau buildup, brain shrinkage and synapse loss, and researchers said existing drugs could be repurposed.
5 Articles
5 Articles
American researchers have discovered that a molecule could not only block cognitive decline, but also mitigate its damage.
A natural brain defense mechanism shows promise against Alzheimer’s damage, revealing a surprising path scientists are exploring.
Scientists discover a protein that protects the brain from Alzheimer’s damage
A protein called SORLA may act as a powerful defense against the toxic tau tangles involved in Alzheimer’s disease. Mice with extra SORLA had less tau accumulation, less brain atrophy, and healthier connections between neurons, while mice without it experienced more severe damage. The findings also revealed a possible drug target that could help control harmful activity in supporting brain cells.
Protein Protects Against Tau Tangles, Synaptic Loss in Mouse Model of Tauopathy
Alzheimer’s disease (AD) and many other forms of neurodegeneration share a common culprit. In these diseases, tau proteins that normally stabilize neuronal microtubule filaments within nervous system networks instead form noxious knots and gradually disrupt the circuits they would otherwise preserve. Scientists at Sanford Burnham Prebys have now shown that a different protein known as SORLA offers protection against the effects of these lethal l…
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